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20 M paeonol increased the enzymatic activities of SOD, CAT, GSH-Px and the expression of HO-1, NQO1, and SOD2 by activating the Nrf2 signaling pathway, but paeonol was unable to affect melanogenesis in PIG1 cells and acted only as a protective agent (Guo and Zhang 2021)
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Since the mid-2000s, the structure of dipeptidyl peptidase-4 (DPP-4, CD26), an enzyme that decomposes GLP-1, has been discovered
Five of these trials have shown superiority in reducing MACE compared to placebo, while all have confirmed the cardiovascular safety of GLP-1 RAs (76)
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